Table 2.
Patient characteristics and univariate analysis of factors related to symptomatic radiation pneumonitis (RP)
| Variables | All patients (n = 56) | RP < Grade 2 (n = 50) | RP ≥ Grade 2 (n = 6) | p-value |
|---|---|---|---|---|
| Age (years) | ||||
| Median (range) | 78 (41–92) | 78 (41–92) | 77 (66–85) | 0.916 |
| Gender | ||||
| Male | 39 | 34 | 5 | 0.656 |
| Female | 17 | 16 | 1 | |
| ECOG PS | ||||
| 0–1 | 48 | 43 | 5 | 1 |
| 2 | 8 | 7 | 1 | |
| History of IP | 7 | 5 | 2 | 0.158 |
| Emphysema | 23 | 20 | 3 | 0.681 |
| Previous lung operation | 13 | 11 | 2 | 0.615 |
| Operable case | 18 | 17 | 1 | 0.652 |
| Histologic type | ||||
| Adenocarcinoma | 25 | 23 | 2 | 0.682 |
| SqCC | 10 | 9 | 1 | 1 |
| Other | 4 | 2 | 2 | 0.053 |
| Unknown | 17 | 16 | 1 | 0.656 |
| Pack years | ||||
| Median (range) | 40 (0–200) | 40 (0–200) | 50 (33–80) | 0.763 |
| Previous FEV 1.0% | ||||
| Mean (range) | 76.9 (16.7–136.9) | 79.9 (16.7–136.9) | 59.7 (39.4–78.3) | 0.1 |
| Previous VC % | ||||
| Mean (range) | 90.4 (53.5–152.2) | 93.2 (58.1–152.2) | 74.8 (53.5–102.3) | 0.034 |
| Tumour location | ||||
| Anterior | 17 | 15 | 2 | 1 |
| Posterior | 39 | 35 | 4 | |
| Superior | 29 | 28 | 1 | 0.096 |
| Inferior | 27 | 22 | 5 | |
| Distance between the tumour and chest wall (mm) | ||||
| Median (Range) | 7.0 (0–45) | 7.0 (0–45) | 4.5 (0–23) | 0.648 |
ECOG, Eastern Cooperative Oncology Group; FEV, forced expiration volume; IP, interstitial pneumonia; PS, performance status; SqCC, squamous cell carcinoma; VC, vital capacity.