Table 5.
Summary of reports on incidence rate and predictive factors of symptomatic radiation pneumonitis (RP)
| First author, reference | Year | N | Total dose/fraction | Equipment | Algorithm | RP Grade 2 | RP Grade 3 or more | Scoring system | Predictive factors |
|---|---|---|---|---|---|---|---|---|---|
| Guckenberger12 | 2010 | 59 | 26 Gy/1 fr | Linear accelerator | AAA | 18.6% | 0.0% | SWOG | MLD |
| 37.5 Gy/3 fr | V2.5–50 | ||||||||
| Matsuo22 | 2012 | 74 | 48 Gy/4 fr | Linear accelerator | AAA | 18.9% | 1.4% | CTCAE3 | PTV |
| V25 | |||||||||
| Barriger11 | 2012 | 251 | 24 72 Gy/3–5 fr | Linear accelerator | NA | 7.0% | 2.4% | CTC2 | MLD |
| V20 | |||||||||
| Chang20 | 2012 | 130 | 50 Gy/4 fr | Linear accelerator | CC | 9.2% | 2.3% | CTCAE3 | MLD |
| V40 | |||||||||
| Takeda17 | 2012 | 128 | 40–60 Gy/5 fr | Linear accelerator | superposition | 16.4% | 5.5% | CTCAE3 | Female |
| High FEV 1 | |||||||||
| Baker10 | 2013 | 263 | 40–60 Gy/4–8 fr | Linear accelerator | PBA | 9.9% | 1.1% | CTCAE3/4 | V5, V13 |
| CC | |||||||||
| Bibault25 | 2012 | 51 | 45–60 Gy/3 fr | CyberKnife | PBA | 3.9% | 0.0% | CTCAE4 | NA |
| Shen26 | 2015 | 50 | 48–60/3 fr | CyberKnife | NA | 6.0% | 4.0% | RTOG | NA |
| Present study | 56 | 48–56/4 fr | CyberKnife | Monte Carlo | 8.9% | 1.8% | CTCAE4 | VC % | |
| V25 |
AAA, analytical anisotropic algorithm; CC, collapsed cone convolution superposition; CTC, Common Toxicity Criteria; CTCAE, Common Terminology Criteria for Adverse Events; FEV 1, forced expiratory volume in 1 s; fr, fractions; MLD, mean lung dose; NA, not available; PBA, pencil beam algorithm; PTV, planning treatment volume; RTOG, Radiation Therapy Oncology Group; SWOG, Southwest Oncology Group; Vx, normal lung volume receiving x Gy of radiation; VC, vital capacity.