Table 2.
Hazard ratios and 95% confidence intervals for GRS and APOE ε4 status on time to death in the ACT study
| Predictors | Pooled analyses (N = 2330) |
Stratified analyses |
||||||
|---|---|---|---|---|---|---|---|---|
| Predementia diagnosis (N = 2330) |
Postdementia diagnosis (N = 526) |
|||||||
| Model 1 |
Model 2 |
Model 3 |
Model 4 |
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| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| AD-GRS | 1.07 (1.01–1.14) | .03 | 1.03 (0.96–1.09) | .43 | 1.04 (0.97–1.12) | .25 | 0.98 (0.88–1.10) | .73 |
| APOE ε4 (yes/no any ε4 alleles) | 1.03 (0.91–1.17) | .64 | 0.88 (0.78–1.01) | <.001 | 0.87 (0.74–1.03) | .10 | 0.83 (0.67–1.03) | .09 |
| CASI score | 0.59 (0.55–0.62) | .07 | ||||||
Abbreviations: ACT, Adult Changes in Thought; AD-GRS, Alzheimer's disease genetic risk score; CASI, Cognitive Abilities Screening Instrument; CI, confidence interval; HR, hazard ratio; SD, standard deviation.
NOTE. All models were adjusted for sex, intake age and age2, wave of genetic data collection, and the first three principal components of population substructure. Models include pooled analyses with and without adjustment for time-dependent CASI score and dementia-stratified analyses.