Table 4.

GRS survival meta-analysis and longevity case/control analysis

Studies	N	Model 1		Model 2
		Effect size∗ (95% CI)	P-value	Effect size∗ (95% CI)	P-value
Survival meta-analysis (ACT and HRS)	7294	1.05 (1.00–1.10)	.04	1.02 (0.97–1.07)	.47
Longevity case/control† (CHARGE)	9793	0.64 (0.41–1.00)	.05

Abbreviations: ACT, Adult Changes in Thought; CHARGE, Cohorts for Heart and Aging Research in Genomic Epidemiology; CI, confidence interval; GRS, genetic risk score; HR, hazard ratio; HRS, Health and Retirement Study; OR, odds ratio.

NOTE. Model 2, but not Model 1, was adjusted for time-dependent cognitive performance.

^∗HRs for survival models and OR for case/control model. Note HRs and ORs are not on the same scale and cannot be directly compared.

^†Controls (died between the ages of 55 and 80 years) are the reference group.