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. 2017 Sep 19;14(9):e1002389. doi: 10.1371/journal.pmed.1002389

Table 1. Characteristics of the included studies.

Lead author(s) [Ref]
Country, Year		 Study Setting Self-monitoring Number of readings / session Co-interventions Pre-defined level Comparison Home target (mmHg) Clinic target (mmHg) Baseline BP ±SD mmHg No. randomised Data available No. 6M No. 12M No. 18M
Halme/ Kantola [41]
Finland, 2005 		HOMER Primary care Daily for 1 week every 2 months 2 None 1 Usual care 135/80 140/85 157/93±18/8 269 231 170 N/A N/A
McManus [24]
UK 2005 		TASMINH Primary care Monthly in GP practice waiting room 2 None 1 Usual care 140/85
140/80 DM		 140/85
140/80 DM		 156/88±15/7 441 440 413 401 N/A
Bosworth [26]
US, 2007 		HINTS Primary care 3 days per week 1 Behavioural intervention 3 Usual care 135/85
135/80 DM		 140/90
135/80 DM		 129/77±18/13 593 591 535 523 N/A
Or meds management 4 130/78±19/14
Or both 4 128/77±19/13
Verberk [25]
Netherlands, 2007 		HOMERUS Primary care and outpatients 1 week per month, then 1 week every 2 months 3 None 1 Usual care with monthly clinic visits then 2 monthly 140/90 140/90 164/96±17/10 517 517 N/A 434 N/A
Green [42]
US, 2008 		eBP Primary care and outpatients 2 days per week 2 Website and email 2 Usual care 135/85 140/90 151/89±12/9 778 778 N/A 730 N/A
+/- web-based pharmacist management 4 151/89±12/9
Bosworth [27]
US, 2009 		TCYB Primary care 3 days per week 1 None 1 Usual care 135/85 140/90 125/71±16/10 636 (476 applicable) 446 383 350 324
Or behavioural interventions, education, and support 4 130/80 DM 130/80 DM 125/71±18/11
Parati & Omboni [33]
Italy, 2009 		TeleBPcare Primary Care 3 days per week 2 Telemonitoring 2 Usual care 135/85 140/90 146/88±12/8 329 298 298 N/A N/A
Godwin [43]
Canada, 2010 		Primary Care At least weekly 1 None 1 Usual care 135/85 140/90 144/81±18/11 552 458 458 458 N/A
Earle [23]
UK, 2010 		Community (recruited through a hospital site) Weekly 1 Blood glucose testing, text/app system with feedback from clinicians 4 Usual care 140/90 140/90 131/77±17/10 137 126 126 N/A N/A
McManus [36]
UK, 2010 		TASMINH2 Primary care Daily for the first week of each month 2 Telemonitoring and self- titration 3 Usual care 130/85
130/75 DM		 140/90
140/80 DM		 152/85±12/9 527 527 480 480 N/A
Hebert [40]
US, 2011 		Outpatients and primary care Variable Not clear None 1 Usual care 140/90 153/86 16/13 416 416 N/A N/A 286
Or nurse support 4 130/80DM 153/86 18/13
Wakefield [31]
US, 2011 		Primary care Daily 1 Low-intensity management algorithm 2 Usual care 135/85 135/85 135/72±18/11 302 300 268 261* N/A
High-intensity algorithm 3 130/80 DM 130/80 DM 136/74±19/11
Bove [44]
US, 2013 		HTN Primary care and outpatients 2 days per week Not clear Telemonitoring 2 Usual care 140/90 155/88±15/11 241 235 202 N/A N/A
Kerry [39]
UK, 2013 		Community (recruited from stroke services) Daily in week 1, then 1 day per week 3 Nurse-led telephone support 2 Usual care 130/80 140/85 138/74±21/12 381 381 352 334 N/A
Magid [50]
US, 2013 		Primary care 3 days per week 1 Patient education and BP reporting; or patient education, BP reporting, and pharmacist management 4 Usual care 135/85
125/75 DM/CKD		 140/90
130/80 DM/ CKD		 147/15±89/10 338 326 326 N/A N/A
Margolis [37]
US, 2013 		Hyperlink Primary care 3 days per week 2 Telemonitoring and pharmacist management 4 Usual care 135/85
125/75 DM/CKD		 140/90
130/80 DM/CKD		 148/85±13/12 450 450 403 388 370
McKinstry [45]
UK, 2013 		HITS Primary care Daily in week 1, then at least 1 day per week thereafter 2 Optional automated telemonitoring 2 Usual care 135/85 140/90 153/91±15/11 401 401 374 N/A N/A
Parati [32]
Italy, 2013 		TeleBPMET Primary care 3 days per week 2 Telemonitoring 2 Usual care 135/85 140/90 147/90±12/8 252 182 181 179 N/A
Green [51]
US, 2014 		eCare At least 1 day per week for 2 months, then 1 day per fortnight for 2 months, then monthly 2 Dietician with BP plan and visits (weekly for 2 months, fortnightly for 2 months, then monthly) 4 Usual care 135/85 140/90 150/92±12/9 101 101 90 N/A N/A
Leiva [46]
Spain, 2014 		Adherencia Primary care Weekly, with morning and afternoon readings 3 Motivational interview, pillbox reminder, family support, BP and medication reminder form, and pharmacist review 3 Usual care 135/85 140/90 and 130/80 for DM or CKD 156/84±15/11 221 215 N/A 215 N/A
McManus [35]
UK 2014 		TASMIN-SR Primary care Daily for the first week of each month 2 Self-management 3 Usual care 120/75 130/80 ST 144/80±13/10 552 450 439 450 N/A
Ogedegbe [34]
US, 2014 		CAATCH Primary care 3 days per week 1 Education, lifestyle, and behavioural support 3 Usual care 151/91±17/10 1,039 997 610 691 N/A
Stewart [48]
Australia, 2014 		HAPPy Primary care Several readings per week 1 Pharmacist management with motivational interviewing, medication review, education, and optional refill reminders 4 Usual care 140/90 and 130/80 for DM and CKD 140/90 and 130/80 for DM and CKD 141/84±20/11 395 391 351 N/A N/A
Yi [47]
US, 2015 		Primary care As prescribed by their doctor Variable Educational material on hypertension 1 Usual care 140/90 or 130/80 DM or CKD 140/90 or 130/80 DM or CKD 152/83±16/11 900 828 529 N/A N/A
Parati (unpublished study)
Italy 		AUPRES Primary care 3 days per week 3 1 Usual care 135/85 140/90 154/95±15/8 407 407 407 407 407

Summary information of included studies. Differences between number randomised and data available for Godwin (2010) and McManus (2014) are due to the use of complete case data only. The difference observed in Bosworth (2009) results from the removal of the behavioural intervention arm and patients with missing baseline BP data. Abbreviations: BP, blood pressure; CKD, chronic kidney disease; DM, diabetes mellitus; GP, general practitioner; M, months; ST, self-tested BP.

*Participants self-monitored for 6 months; follow-up data collected at 12 months.