Figure 6.

Relationship between tumour “stem-like” cells and tumour control for a group of first passage mouse mammary tumours in C3H mice. (a) The relationship between the single radiation dose given under hypoxic conditions required to cure 50% of the tumours (TCD₅₀ value) and the number of cells required to be injected to generate growth of tumours in 50% of injection sites (TD₅₀ value). The slope of the line is consistent with the radiation sensitivity of hypoxic cells. (b) The relationship between the in vitro plating efficiency and the TD₅₀ value for the same group of tumours. Modified from Hill and Milas⁷² with permission from Elsevier.