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(A) A synthetic oligomer containing a uracil was treated with Ung to create an AP site and the AP site cleaved by APE-1 in the presence or absence of the inhibitor CRT0044876 (100 μM). (B) Raji cells were treated with different concentrations of CRT0044876 dissolved in DMSO and the viability of the cells after 24 hr treatment is presented. “DMSO” represents viability of cells following treatment with 1% DMSO alone.
