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. 2017 Sep 19;12(9):e0184916. doi: 10.1371/journal.pone.0184916

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© 2017 Chen et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — Expansion (A) Representative composite image of the wild type mouse cornea shows KRT12 expressed throughout the peripheral (pC) and central cornea (cCo), while KRT19 is restricted to the conjunctival (Cj) and limbal (Lm) epithelia. (B) Magnified images of corneal limbal region show extension of KRT19 into the peripheral cornea (pC) of Aire -/- mice (upper panel, delineated using a dotted line). Same images shown in the lower panel reveal the length of KRT19-KRT12 overlap (delineated using a dotted line) is significantly less in WT compared to Aire -/-. (C) The KRT19/KRT12 ratio was used as a readout to assess extension of KRT19+ ePCs into the peripheral cornea. Data are expressed as means±SEM. n = 3–4 mice per group. *p<0.05. Scale bar = 50 μm.