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. 2017 Sep 19;12(9):e0184916. doi: 10.1371/journal.pone.0184916

Fig 5. Topical steroid stimulates neurite outgrowth in the Aire -/- cornea.

Fig 5

Confocal images of whole mount corneas immunolabeled for TUBB3 show that twice-daily topical application of 1% prednisolone acetate significantly increases corneal innervation in Aire.BalbC -/- mice. Corneal epithelial nerve fiber density in Aire -/- mice treated with vehicle (Aire -/- + Vehicle) was used as the reference and data expressed as the mean±SEM fold change relative to Aire -/- + Vehicle. n = 3–4 mice per group. *p<0.05. Scale bar = 50 μm.