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. Author manuscript; available in PMC: 2017 Sep 19.
Published in final edited form as: J Med Chem. 2017 Jul 11;60(14):6191–6204. doi: 10.1021/acs.jmedchem.7b00435

Scheme 1.

Scheme 1

Synthesis of 4-(N-piperidinyl)methyl benzamide derivatives.a aReagents and conditions: (i) piperidine, CH2Cl2, reflux, 75%; (ii) NaOH, MeOH/H2O, rt, 87%; (iii) benzylamines or phenylethylamines, HATU, DIEA, CH2Cl2, rt, 70–80%.