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. Author manuscript; available in PMC: 2017 Sep 19.
Published in final edited form as: J Med Chem. 2017 Jul 11;60(14):6191–6204. doi: 10.1021/acs.jmedchem.7b00435

Scheme 3.

Scheme 3

Synthesis of 2-(N-piperidinyl)methyl benzamide derivatives.a

aReagents and conditions: (i) piperidine, K2CO3, THF, rt, 76%; (ii) NaOH, MeOH/H2O, rt, 89%; (iii) 4-chlorobenzylamine, HATU, DIEA, CH2Cl2, rt, 73%.