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. Author manuscript; available in PMC: 2017 Sep 19.
Published in final edited form as: J Med Chem. 2017 Jul 11;60(14):6191–6204. doi: 10.1021/acs.jmedchem.7b00435

Table 1.

Activity of N-benzylbenzamide derivatives 8a–8h on the survival of INS-1 cells treated with Tm.a

graphic file with name nihms903857u1.jpg
Compd R1 R2 Maximum activity
(% rescue)a 		EC50
(µM)b
1 graphic file with name nihms903857t1.jpg 3-Cl 42% ± 12% 21 ± 5.7
8a graphic file with name nihms903857t2.jpg H 47% ± 9% 19 ± 6.9
8b graphic file with name nihms903857t3.jpg 2-OMe 29% ± 6% >30
8c graphic file with name nihms903857t4.jpg 4-F 50% ± 11% 21 ± 3.2
8d graphic file with name nihms903857t5.jpg 4-Cl 51% ± 17% 15 ± 1.6
8e graphic file with name nihms903857t6.jpg 4-OMe 26% ± 8% >30
8f graphic file with name nihms903857t7.jpg 3,4-Di-OMe 5% ± 7% >30
8g graphic file with name nihms903857t8.jpg 3-Cl 41% ± 14% 25 ± 5.2
8h 3,4-Di-OMe 3-Cl 46% ± 17% 24 ± 2.1