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. Author manuscript; available in PMC: 2017 Sep 19.
Published in final edited form as: J Med Chem. 2017 Jul 11;60(14):6191–6204. doi: 10.1021/acs.jmedchem.7b00435

Table 3.

Activity of N-phenethylbenzamide derivatives 10a–10p on the survival of INS-1 cells treated with Tm.

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Compd R Maximum activity
(% rescue)		 EC50 (µM)
10a 2-Me 6% ± 5% -
10b 2-S-iPr 30% ± 8% >30
10c 3-F <0 -
10d 3-NO2 <0 -
10e 3-NH2 <0 -
10f 3-OEt 49% ± 11% 26 ± 4.5
10g 3-NHSO2Me 24% ± 8% 25 ± 2.1
10h 4-Me 25% ± 5% 20 ± 5.4
10i 4-O-propargyl 54% ± 8% >30
10j 4SO2-NMe2 37% ± 6% 19 ± 2.1
10k 4-(N-pyrrolidinyl)methyl 31% ± 7% 11 ± 1.9
10l 4-(N-piperidinyl)methyl 87% ± 9% 21 ± 3.5
10m 3,4-Di-Cl 42% ± 11% 17 ± 6.1
10n 3-Me-4-OMe 56% ± 8% 15 ± 3.2
10o 2,3,4-trifluoro 23% ± 6% 9.9 ± 2.1
10p 2,3,4,5-tetrafluoro <0 -