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Salsalate impedes hepatic gluconeogenesis. (a) Salsalate inhibits glucose production from pyruvate. (b–c) The mRNA (b) and protein (c) levels of PGC-1α, G6Pase and PEPCK. (d) Densitometric quantification of the immunoblots in (c). (e) Salsalate down-regulates gluconeogenic gene expression in the starved HepG2 cells. (f) Salsalate inhibits glucose production in the starved HepG2 cells. Data are expressed as mean ± SEM (n = 5). *P < 0.05 and **P < 0.01 by two-tailed Student's t-test.
