Fig. 7.

Role of IL-17 from neutrophils in development of CIA during MTB H37Rv infection. (a) CIA was induced in 6-week-old WT mice infected with or without MTB H37Rv and arthritis scores of diseased mice were evaluated. (b–d) CIA was induced in Cd18^−/− mice infected with MTB H37Rv, and then were given no neutrophils (Ctrl) or given intravenous injection of 2 × 10⁶ WT or Il17a^−/− bone marrow neutrophils every two days. (b) Arthritis scores of diseased mice were evaluated. (c) Concentrations of IL-17 in serum were quantified. (d) Histologic sections of arthritic joint from the CIA mice with severe arthritis stained with hematoxylin and eosin (H&E). Scale bars: 1 mm. Data shown in are the mean ± SEM. *P < 0.05; **P < 0.01. Data are representative of three independent experiments with similar results.