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. 2017 Aug 9;23:160–172. doi: 10.1016/j.ebiom.2017.08.011

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Handelin activates Hsp70 by allosteric effect. (a) Fluorescence spectroscopy analysis of the interaction of Hsp70 with handelin. Fluorescence for recombinant human Hsp70 protein treated or untreated with various concentrations of handelin was collected. (b) Representative conformations of NBD (ADP) in handelin bound Hsp70 system obtained by 100 ns of MD simulations using Amber14. (c) Effects of handelin on the ADP of Hsp70 measured using a colorimetric assay. (d) Effects of handelin on the ATPase activity of Hsp70 measured using a malachite assay.