Table 1.
Representative MMP and cathepsin K cleavage sites within collagen triple-helical domains.
| Enzyme | Collagen Chain (collagen type) | Sequencea |
|---|---|---|
| MMP-1, -2, -8, -9, -12, -13, MT1-MMP | α1(I) | Pro-Gln-Gly775~Ile776-Ala-Gly |
| MMP-1, -2, -8, -9, -12, -13, MT1-MMP | α2(I) | Pro-Gln-Gly775~Leu776-Leu-Gly |
| MMP-1, -8, -13, MT1-MMP | α1(II) | Pro-Gln-Gly775~Leu776-Ala-Gly |
| MMP-1, -8, -9, -12, -13, MT1-MMP, MT3-MMP | α1(III) | Pro-Leu-Gly775~Ile776-Ala-Gly |
| MMP-9 | α1(V) | Pro-Pro-Gly439~Val440-Val-Gly |
| MMP-9 | α2(V) | Pro-Pro-Gly445~Leu446-Arg-Gly |
| Cathepsin K | α1(I) | Gly-Pro-Arg9~Gly10-Leu-Pro |
| Cathepsin K | α1(I) | Gly-Pro-Gln21~Gly22-Phe-Gln |
| Cathepsin K | α1(I) | Gly-Leu-Asp96~Gly97-Ala-Lys |
| Cathepsin K | α1(I) | Gly-Pro-Gln189~Gly190-Val-Arg |
| Cathepsin K | α1(I) | Gly-Pro-Ser810~Gly811-Ala-Ser |
| Cathepsin K | α2(I) | Gly-Pro-Arg9~Gly10-Pro-Pro |
| Cathepsin K | α2(I) | Gly-Pro-Gln21~Gly22-Phe-Gln |
| Cathepsin K | α2(I) | Gly-Leu-Lys99~Gly100-Pro-Gln |
| Cathepsin K | α2(I) | Gly-Ala-Arg144~Gly145-Ser-Asp |
| Cathepsin K | α2(I) | Pro-Pro-Gly814~Ala815-Arg-Gly |
| Cathepsin K | α1(II) | Lys-Pro-Gly61~Lys62-Ser-Gly |
a
Numbering begins at the N-terminus of the triple-helical region of each collagen.