Figure 2.

Comparisons of the effects of estradiol treatment, treadmill exercise, and ER antagonist ICI 182,780 (ICI) treatment on the number of labeled motoneurons in males (A) and females (B). The mean (± standard deviations) number of motoneurons labeled by tracer application to the transected and repaired CF nerve 1.5 mm distal to the original cut site (hashed bars) and to the intact CF nerve (solid bars) for males (A) and females (B) are shown. No treatment altered the number of labeled motoneurons in the intact side in either sex. No differences were found in the number of labeled motoneurons between the intact side and the transected and repaired side in mice treated with estradiol or with treadmill exercise using the continuous paradigm (A) or interval paradigm (B). Significantly fewer motoneurons were labeled in the transected and repaired side in mice treated with ICI compared to the intact side of the same animals. * p ≤ 0.04 ; ** p ≤0.0001