Fig. 6. DRG neuronal responses to H₂O₂ (1 mM), capsaicin (0.5 μM) and allyl isothiocyanate (AITC; 100 μM).

(A) Example traces of response to H₂O₂ and capsaicin (CAPS; 20-second application of each) of individual, dissociated lumbar 3–5 DRG neurons during Fura-2 Ca²⁺ imaging. (B) Venn diagrams illustrating the overlap of cells exhibiting Ca²⁺ transients in response to H₂O₂ and capsaicin. (C) Percentage of cells that responded both to H₂O₂ and capsaicin (blue column), that responded to H₂O₂ but not to capsaicin green column), and that responded to capsaicin but not to H₂O₂ (red column). (D) Example traces in response to H₂O₂ and AITC (20-second duration of each) of individual, dissociated lumbar 3–5 DRG neurons during Fura-2 Ca²⁺ imaging. (E) Venn diagrams illustrating the overlap of cells exhibiting Ca²⁺ transients in response to H₂O₂ and AITC. (F) Percentage of cells that responded to both H₂O₂ and AITC (blue column), that responded to H₂O₂ but not to AITC (green column), and that responded to AITC but not to H₂O₂ (red column).