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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: J Immunol. 2017 Aug 16;199(7):2305–2315. doi: 10.4049/jimmunol.1700833

Fig. 8. Schematic of ADAM10-mediated ICOS/ICOSL regulation/mechanism.

Fig. 8

A) T cell ICOS interacts with B cell ICOSL in the secondary lymphoid organs. Upon ICOS/ICOSL interaction, ICOS is internalized to regulate the level on T cells. ADAM10 cleaves surface ICOSL to maintain low surface expression. B) When ADAM10 is knocked out on B cells, surface ICOSL accumulates because it is no longer being cleaved. Additionally, ADAM10B−/− B cells reduce the level of Icosl transcription. Higher levels of ICOSL leads to increased ICOS interaction, causing T cells to dramatically increase internalization of ICOS.