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. Author manuscript; available in PMC: 2018 Sep 19.
Published in final edited form as: Biochemistry. 2017 Sep 6;56(37):4940–4950. doi: 10.1021/acs.biochem.7b00695

Scheme 2. Proposed Scheme for the Reaction of CmlIox with NH(OH)-CAMa.

Scheme 2

aFor the sake of simplicity CmlIox and CmlIred are abbreviated as Eox and Ered, respectively. The intermediate Eox-NH(OH)-CAM' and the assignment of the rate constant for the reduction step as “fast” are proposed on the basis modeling of the overall biosynthetic reaction pathway kinetics (see Discussion, Simulation of the Overall Reaction).