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. Author manuscript; available in PMC: 2018 Oct 11.
Published in final edited form as: Neuroscience. 2017 Aug 5;361:116–128. doi: 10.1016/j.neuroscience.2017.07.071

Figure 2.

Figure 2

Locomotion scores as a function of prenatal dietary condition and high dose MK-801 or saline administration. Scores of standard-fed rats are shown in the top panel (A and B) and scores of prenatal choline-supplemented rats are shown in the bottom panel (C and D). The left panels (A and C) show scores of saline- and MK-801-treated rats collected at each of the 37 time points (one every 5 min for 3 hr) and the right panels (B and D) show the mean scores over time. Overall MK-801 significantly increased locomotion, particularly in early portions of the observation period for both diet conditions; this reduction was significantly attenuated in rats treated with prenatal choline supplementation. *p < 0.05 STD-MK-801 versus STD-SAL and SUP-MK-801