Table 1.
Clinical characteristics of matched patient pairs
| Variable | Standard Dose (n = 76) | Concomitant Boost (n = 76) | P-value |
|---|---|---|---|
| Age (y) | 57.1±13.0 | 55.9±11.7 | .54 |
| Sex (male) | 49 (64.5%) | 50 (65.8%) | .86 |
| Ethnicity/Race (Caucasian) | 62 (81.6%) | 68 (89.5%) | .17 |
| T Stage | Matched | ||
| T2 | 2 (2.6%) | 2 (2.6%) | |
| T3 | 71 (93.4%) | 71 (93.4%) | |
| T4 | 3 (4.0%) | 3 (4.0%) | |
| N Stage | Matched | ||
| N0 | 42 (55.3%) | 42 (55.3%) | |
| N1 | 34 (44.7%) | 34 (44.7%) | |
| AJCC Stage | Matched | ||
| I (T1-T2, N0, M0) | 1 (1.3%) | 1 (1.3%) | |
| IIA (T3, N0, M0) | 39 (51.3%) | 39 (51.3%) | |
| IIB (T4, N0, M0) | 2 (2.6%) | 2 (2.6%) | |
| IIIA (T1-T2, N1, M0) | 1 (1.3%) | 1 (1.3%) | |
| IIIB (T3-T4, N1, M0) | 33 (43.4%) | 33 (43.4%) | |
| Operative procedure | |||
| Low anterior resection | 19 (25.0%) | 19 (25.0%) | |
| Abdominoperineal resection | 21 (27.6%) | 21 (27.6%) | 1 |
| Proctectomy with coloanal anastomosis | 36 (47.4%) | 36 (47.4%) | |
| Distance from anal verge (cm) | 5.7 ± 3.1 | 4.7 ± 2.5 | .02 |
| Circumferential involvement (%) | 54.4 ± 20.5 (n = 41) | 58.4 ± 22.2 (n = 36) | .41 |
| Tumor length (cm) | 5.1 ± 2.6 (n = 45) | 5.1 ± 2.0 (n = 54) | .97 |
| Time from radiation therapy to surgery | 48 (24-83) | 42 (24-256) | .67 |
| Duration of chemoradiation therapy (d), (range) | 35 (22-42) | 35 (31-42) | .80 |
AJCC, American Joint Committee on Cancer.