Table 4.
β-Catenin Mutations in PC and Their Impact on PC Death and Recurrence.
| Patient Cohort | n | Mutation (n); Patient | Survival or Recurrence |
|---|---|---|---|
| Michigan, Nature 2012 | 59 | T41A (1) | Deceased (OS 15 months) |
| D32Y (1) | Deceased (OS 69 months) | ||
| N387 K (1) | Deceased (OS 41 months) | ||
| Robinson et al., Cell 2015 | 150 | T41A (2) | NA |
| S37C (1) | NA | ||
| S45C (1) | NA | ||
| S45F (1) | NA | ||
| FH, Nat Med 2016 | 56 | T41A (1) | NA |
| D32V (1) | NA | ||
| M14 V;S37Y (1) | NA | ||
| S45P (1) | NA | ||
| M763I (1) | NA | ||
| Trento/Cornell/Broad 2016 | 81 | T41A (1) | NA |
| D32N (1) | NA | ||
| S33A (1) | NA | ||
| MSKCC, Cancer cell 2010 | 103 | A522T;S45P | NA |
| W383G (1) | Recurred | ||
| CPC-GENE, Nature 2017 | 449 | T41A (1) | NA |
| TCGA provisional | 489 | T41A (1); HC-7738a | Recurred, DF:13.8 months |
| T41A (1); EJ-A65Da | DF, censored: 12.9 months | ||
| D32Y (1), HC-8262a | DF, censored: 22.3 months | ||
| D32V (1), EJ-5494a | DF, censored: 48.5 months | ||
| D32H (1), EJ-5525a | Recurred, DF: 17.9 months | ||
| S33A (1) | DF; censored: 41 months | ||
| S33Y (1) | DF; censored: 21.8 months | ||
| S33C (1) | Recurred; DF: 18.4 months | ||
| S45P (1) | DF | ||
| R225H (1) | Recurred | ||
| R342K (1) | DF | ||
| T75I (1) | DF |
All cohorts were extracted from cBioPortal.
Frequently mutated resides are bolded.
n, number of patients; Mutation (n), number of cases with the indicated mutations.
a
Patient ID is included only for patients with PC containing either T41A or missense mutations in D32 within the TCGA dataset.