Table 5.

Univariate and Multivariate Cox Analysis of the Nine-Gene Signature for PC Recurrence

		Univariate			Multivariate
Clinical Variables	na	HR	95% CI	P Value	HR	CI (95%)	P Value
The 9-gene sigb
0	390
1	95	2.381	1.547-3.684	3.47e-5*	1.731	1.104-2.712	.0167*
Tumor stagec
≤ T2	184
T3 and T4	295	3.93	2.178-7.102	5.57e-6*	1.919	0.994-3.683	.0502
Age at diagnosis	485	1.025	0.993-1.058	.128	1.002	0.970-1.036	.8879
RP GSd	485	2.209	1.773-2.752	1.57e-12*	1.874	1.430-2.360	1.93e-6*
Margin statuse
0	208
1	147	2.162	1.418-3.296	.00034*	1.271	0.798-1.993	.3203

^aNumber of cases.

^bThe nine-gene signature. 0: signature-negative; 1: signature-positive.

^cSix cases without stage information.

^dRadical prostatectomy Gleason score.

^eSurgical margin status: 0, R0; 1, R1 and R2; NA, case without surgical margin information and Rx (n = 30).