Fig. 6.

Ptf1a ^CreER-mediated clonal analysis identifies unipotent acinar progenitors at E11.5. a Schematic overview of strategy applied to identify fates of clonal progeny from E11.5 pancreatic progenitors. b Quantification of clone sizes and fate compositions following Ptf1a ^CreER-mediated clonal analysis (n = 24 clones in 70 embryos analysed). Arrows indicate two acinar unipotent acinar clones, as predicted by our mathematical model. c A representative 3D MIP of one of the two acinar unipotent clones. Most clones were found in the dorsal pancreas, except clones no. 2, 9 and 16 which were found in the ventral pancreas. Scale bars, 20 µm