Fig. 8.

Proposed model of orchestration of pancreas organogenesis by heterogeneous clones. Although initially possessing the same intrinsic potency, the spatial position of induced clones in the pancreatic bud influences expressed in vivo potency by dispersing clonal progeny to different niches. While peripherally labelled cells (yellow outline) will be exposed to acinar-inducing cues concomitant with generation of trunk-fated progeny during branching morphogenesis, centrally labelled cells (red outline) are less likely to experience acinar-inducing signals and thus produce ducto-endocrine bipotent clones. Stochastic priming of centrally located progenitors towards the endocrine lineage might further generate heterogeneity in clonal contribution to the ductal and endocrine lineage