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. 2017 Sep 19;7:11906. doi: 10.1038/s41598-017-12106-y

Figure 1.

Figure 1

Effects of ipragliflozin on food and water intakes, activity, and body temperature during dark and light periods in normal and GK rats. (a) Daily food intake during dark (left) and light (right) periods. **P < 0.05 vs. Wistar + vehicle; dark period, days 1, 3, 4, 13, 15, 17, 18, and 20; light period, days −2, 3–6, 13, 16, and 18. †† P < 0.05 vs. GK + vehicle; dark period, days −2, 3, 8–15, and 17–20. (b) Total food intake during the entire period, days 1–20. **P < 0.01 vs. Wistar + vehicle, †† P < 0.01 vs. GK + vehicle. (c) Daily water intake during dark (left) and light (right) periods. **P < 0.05 vs. Wistar + vehicle; dark period, days −2, −1, 1, 3, and 5–20; light period, days −2, 1–13, and 16–20. †† P < 0.05 vs. GK + vehicle; dark period, days 2–20; light period, days 6–8, 15, 17, 19, and 20. (d) Total water intake during the entire period, days 1–20. **P < 0.01 vs. Wistar + vehicle, †† P < 0.01 vs. GK + vehicle. (e) Daily activity during dark (left) and light (right) periods. *P < 0.05 vs. Wistar + vehicle; dark period, days 16, 17, and 19; light period, days −3, 1, 2, 5, and 8. (f) Body temperature during dark (left) and light (right) periods. **P < 0.05 vs. Wistar + vehicle; dark period, days −1, 1–11, 13, 17, and 19; light period, days 8, 9, 11, 13, 15, 16, and 19. Values are expressed as mean ± standard error of the mean (s.e.m.). n = 4 per group.