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. 2017 Sep 19;7:11893. doi: 10.1038/s41598-017-12131-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CISD2 expression is upregulated in lung ADC and associated with poor prognosis. (A) Box plot showing upregulation of CISD2 mRNA expression levels in lung ADC tumor tissues compared with those in normal lung tissues, based on public domain data GSE31210. Data were downloaded from Oncomine and analyzed directly without further processing. (B) RT-qPCR assay of CISD2 mRNA expression of samples from our previously used cohort of 56 specimens containing 28 lung ADC and 28 normal lung tissues (not matched pair). (C) Representative images of IHC staining of CISD2 protein performed on normal and lung ADC tissues. Scale bar: 50 μm. (D) A summary of IHC analysis of CISD2 protein expression in lung ADC and normal lung tissues in commercial tissue microarrays (c.f. Materials and Methods). (E and F) Survival analysis on CISD2 mRNA expression and recurrence-free survival using public domain data. In each dataset, patients were stratified into low CISD2 (solid line) and high CISD2 (dashed line) groups using median CISD2 expression level as cutoff; significance of difference in survival between groups was estimated using log rank test. For (A), (B) and (D) p values were obtained using Student’s t-test, ***P < 0.001. Detailed information about public domain datasets is available in Supplementary Table S1.