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. 2017 Sep 19;8:583. doi: 10.1038/s41467-017-00690-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — RNA localization as the key determinant of protein localization and potential functional roles for RBPs. Scheme illustrating the contribution of mRNA localization to neurite-localized proteome. Neurite-localized proteins (proteomics log2 neurites/soma > 1, P-values < 0.05) were split into three groups based on encoding mRNA localization pattern (upper panel): proteins encoded by localized mRNAs (RNA-seq log2 neurites/soma > 1, P-values < 0.05), proteins encoded by moderately enriched mRNA (0 < RNA-seq log2 neurites/soma < 1), and proteins localized to neurites without a significant contribution of mRNA localization (RNA-seq log2 neurites/soma < 0). Boxplot (middle panel) shows mean Ribo-seq log2 neurites/soma values for these three gene categories. Neuron schematic representation (lower panel) illustrates the predominant mechanism of protein localization through local translation of neurite-localized mRNAs