. 2017 Sep 15;8:1759. doi: 10.3389/fmicb.2017.01759

Table 2.

Antifungal activity of tacrolimus, cyclosporine A, itraconazole, and fluconazole – as monotherapy and in their most effective combination – against S. brasiliensis and S. schenckii reference isolates.

	MIC^a (mg/L)

	TAC^b	CYC^c	ITC^d	FLC^e	TAC/ITC (FICI^f)	TAC/FLC (FICI^f)	CYC/ITC (FICI^f)	CYC/FLC (FICI^f)
S. brasiliensis CBS 133021	1	1	0.125	16	0.25/0.002 (0.27)	0.25/0.25 (0.27)	0.125/0.125 (1.13)	0.125/16 (1.13)
S. schenckii CBS 132984	2	1	0.25	32	0.25/0.001 (0.13)	0.25/0.125 (0.13)	0.125/0.25 (1.13)	0.125/32 (1.13)

^aMIC, minimum inhibitory concentration, defined as the concentration that inhibited ≥50% of yeast growth (shown as the median of two or more independent experiments); ^bTAC, tacrolimus; ^cCYC, cyclosporine A; ^dITC, itraconazole; ^eFLC, fluconazole; ^fFICI, fractional inhibitory concentration index = (MIC_x in combination/MIC_x alone) + (MIC_y in combination/MIC_y alone, where x is tacrolimus or cyclosporine A; and y is itraconazole or fluconazole. Interactions were considered synergistic if FICI ≤ 0.5.