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. 2017 Sep 19;7:11889. doi: 10.1038/s41598-017-12349-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of MI-2 on CIA in a DBA/1 J mouse model. (a) Photographs of the paws of CIA mice treated with vehicle or MI-2. (b) CIA scores in CIA mice treated with vehicle (n = 6) or MI-2 (n = 6). (c) Haematoxylin and eosin-stained sections of a CIA joint 42 d after primary immunisation in CIA mice treated with vehicle or MI-2 by intraperitoneal injection of 25 mpk once per day initiated 24 d after primary immunisation. B: bone, ST: synovial tissue, JC: joint cavity, arrows: sites of inflammation, arrow heads: lining layers of the synovial tissue. (d) TRAP-stained sections of a CIA joint 42 d after primary immunisation in CIA mice treated with vehicle or MI-2 by intraperitoneal injection of 25 mpk once per day, initiated 24 d after primary immunisation. B: bone, arrows: TRAP-positive sites, (e) Evaluation of synovitis and erosion of bone and cartilage in joint sections in CIA mice treated for 18 d as indicated. *, significant differences based on 2-tailed unpaired Student’s t-tests at P < 0.05. The error bars show the s.e.m. values.