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. 2017 Sep 19;8:607. doi: 10.1038/s41467-017-00452-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Knock-down of FGFR-3 in melanoma cells restores sensitivity to signaling inhibitors. a, b Knock-down of FGFR-3 rescues the sensitivity to BRAFi and MEKi. Dose responses to BRAFi and MEKi of melanoma cell lines (451Lu (a) and WM989 (b) stably transduced with FGFR-3 shRNA (blue lines) were determined as in Fig. 5 and compared with control shRNA-transduction (red lines). For validation of the FGFR-3 shRNA clone see Supplementary Fig. 10