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. 2017 Sep 19;8:607. doi: 10.1038/s41467-017-00452-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Clinical activity of CD20 immunotargeting in metastatic melanoma patients. PET-CT scans from two different patients obtained pre- vs. post-anti-CD20 antibody therapy. a, b Note complete disappearance of a metabolically active metastatic site (white arrow); c, d mixed response with almost complete disappearance of one metabolically active metastatic site (white arrow in d) and simultaneous increase in size and metabolic activity of the other (red arrow in d). e Representative combined PAX5 (nuclear; purple)/CD20 (membrane; yellow) immunofluoresence staining of patient-matched melanoma samples before and after therapy with anti-CD20 antibody (overviews (top rows; scale bars: 100 μm) and corresponding close ups (bottom rows; scale bars: 10 μm)). Note depletion of TAB cells in post-therapy tumors. CSPG staining of melanoma cells (green) and nuclear DAPI staining (blue). Right panel: double positive PAX5 (nuclear)/CD20 (membrane) immunofluoresent TAB cells