Table 2.
In vitro and in vivo toxicity of amphotericin B formulations.
| AmB Formulation | IC50 (mg/L of amphotericin B) against mammalian cell linea | MTD (mg/kg of amphotericin B)b | |
|---|---|---|---|
| HEK-293 cell line | J774A.1 cell line | ||
| Fungizone | 26.5 | 22.5 | 2 |
| AmBisome | 201 | >200 | >15 |
| AmB-NA3 | 120 | >200 | 15 |
| AmB-NA5 | 176 | >200 | 15 |
a In vitro toxicity of different formulations of amphotericin B towards mammalian (J774A.1 and HEK-293) cell lines after 24 h of incubation (IC50) using the MTT test.
b In vivo toxicity (Maximum tolerated dose, MTD) of different formulations of amphotericin B in Balb/c female mice after a single bolus injection; values are calculated from the number of mice surviving the injection.