Table 4.

Hematological parameters on post-injection effects at day 8 after seven doses (1, 5, and 10 mg/kg/day of AmB).

Parametersa	Dose (mg/kg/day)	Fungizone	AmBisome	AmB-NA3	AmB-NA5	Controlc
RBCb (×106/mL)	1	4.03 ± 0.4*	7.38 ± 1.8	7.45 ± 0.9	7.31 ± 1.3	7.47 ± 0.2
	5	—	6.58 ± 0.7	7.01 ± 1.1	7.06 ± 1.6
	10	—	4.41 ± 1.7	7.00 ± 0.6	6.90 ± 0.2
WBCsb (×103/μL)	1	4.17 ± 0.6*	6.20 ± 0.8	6.20 ± 1.5	6.40 ± 2.2	6.7 ± 0.4
	5	—	6.00 ± 0.6	6.10 ± 0.4	6.20 ± 0.1
	10	—	5.7 ± 0.9	5.80 ± 0.8	6.00 ± 1.2
Platelet (×103/μL)	1	155 ± 21*	460 ± 24	400 ± 35	442 ± 45	507 ± 24
	5	—	410 ± 11	305 ± 16	398 ± 23
	10	—	342 ± 32*	220 ± 22*	312 ± 12*
Hematocrit (%)	1	24.4 ± 2.9*	40.3 ± 0.5	41.6 ± 1.2	44.6 ± 2.1	46.2 ± 2.4
	5	—	35.5 ± 2.0	41.0 ± 0.6	43.2 ± 2.8
	10	—	36.5 ± 2.8	39.1 ± 2.9	42.0 ± 1.2
Hemoglobin (g/dL)	1	11.5 ± 1.1*	16.4 ± 0.9	16.9 ± 1.2	17.1 ± 0.4	17.2 ± 1.2
	5	—	16.0 ± 0.3	16.5 ± 0.7	16.8 ± 0.9
	10	—	15.3 ± 2.2	16.2 ± 1.1	16.5 ± 1.4

The commercial formulation of Amphotericin B, Fungizone was given at dose of 1 mg/kg for 7 days.

^aAll parameters were expressed as mean values ± SD.

^bRBC, red blood cells; WBC, white blood cells.

^cControl groups received only PBS.

*Significant at P < 0.05, Students t test.