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. 2017 Sep 15;8:1138. doi: 10.3389/fimmu.2017.01138

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Copyright © 2017 Shah, Herasimtschuk, Boasso, Benlahrech, Fuchs, Imami and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Gradual increase in T cell activation and pro-apoptotic marker expression during normal pregnancy. (A) Changes in activation markers CD38, HLA-DR, and CD69 expression in CD4 and CD8 T cells with trimesters and compared to controls. (B) Plasma neopterin concentration in pregnancy correlated with CD38 mean florescence intensity (MFI) on CD4⁺ T cells. (C) FAS and CD57 marker expression on CD4 and CD8 T cells during pregnancy and compared to health controls (HCs). Columns indicate median and error bars interquartile range. ^♯♯p < 0.01 (Kruskal–Wallis one way analysis of variance and Dunn’s test for multiple comparisons). Abbreviation: Pr, pregnant.