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. 2017 Sep 15;8:1138. doi: 10.3389/fimmu.2017.01138

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Copyright © 2017 Shah, Herasimtschuk, Boasso, Benlahrech, Fuchs, Imami and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proportions of myeloid dendritic cell (mDC) and costimulatory CD86 expression on plasmacytoid DC (pDC) were reduced in pregnancy but positively correlated with indoleamine 2,3-dioxygenase (IDO) activity. (A) Proportions of mDC and pDC and their respective expression of CD86 in pregnancy and compared to controls. (B) Correlation between CD86 expression on DCs and plasma neopterin concentration. (C) Correlation between mDC proportions, CD86 expression, and plasma kynurenine/tryptophan ratio (KTR). (D) Plasma tryptophan, kyurenine concentration, and KTR (μmol/mmol) during pregnancy. Columns indicate median and error bars interquartile range. ^♯♯p < 0.01 (Kruskal–Wallis one way analysis of variance and Dunn’s test for multiple comparisons), *p < 0.05 (Mann–Whitney U). Abbreviations: HC, healthy control; MFI, mean florescence intensity; Pr, pregnant.