Table 3.
Mouse PR-A and PR-B interact with hypothalamic proteins, identified by RPPA, in a ligand-dependent manner, with a ratio of R5020/no ligand ≥2 and p < 0.05.
Transcription | UniProt symbol | UniProt ID | PR-A (R5020/no ligand) | PR-B (R5020/no ligand) |
Steroid-receptor coactivator-1 | NCOA1 | P70365 | + | + |
Steroid receptor coactivator-2 | NCOA2 | Q61026 | + | + |
Thyroid hormone receptor-associated protein complex | MED12 | A2AGH6 | + | |
c-Fosp | FOS | P01101 | + | |
c-Junp | JUN | P05627 | + | |
Kruppel-like factor 4 | KLF4 | Q60793 | + | |
Autophagy-related protein 3 | ATG3 | Q9CPX6 | + | |
Autophagy related protein 12 | ATG12 | Q9CQY1 | + | |
BCL2 antagonist/killer 1 | BAK | O08734 | + | + |
Forkhead box O1 (metabolism) | FOXO1 | Q9R1E0 | + | + |
Signal transduction | ||||
Src kinasep | SRC | P05480 | + | |
Signal transducer and activator of transcription 2p | STAT2 | Q9WVL2 | + | |
Epidermal growth factor receptor | EGFR | Q01279 | + | |
p70S6 kinasep | KS6B | Q8BSK8 | + | |
Integrin-α5 | ITA5 | P11688 | + | |
Cyclin C | CCNC | Q62447 | + |
pProteins identified with phospho-specific antibodies. Table 3-1 shows proteins identified by RPPA that associate with PR in the absence of ligand.