Key Resources Table

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-acetyllysine	Cell Signaling	9441
Anti-ATP5α	Mitoscience	MS502
Anti-histone H3	Upstate	07-690
Chemicals, Peptides, and Recombinant Proteins
Control diet (custom)	Envigo	TD.150345
High-fat diet (75% kcal fat, custom)	Envigo	TD.160153
Ketogenic diet (90% kcal fat, custom)	Envigo	TD.160239
Critical Commercial Assays
LiquiColor Beta-Hydroxybutyrate colorimetric test	StanBio	2440-058
Deposited Data
RNAseq fastq files and processed expression data	GEO	GSE101657
Experimental Models: Organisms/Strains
C57BL/6 male mice	NIA Aged Rodent Colony	N/A
Oligonucleotides
See Table S4
Software and Algorithms
Prism	GraphPad	7.0a
Stata/SE	Stata Corp	14.2
Perl	Perl.org	5.16.1
Ingenuity Pathway Analysis	Ingenuity	2017
AmiGO	Gene Ontology	1.8