Milk-associated proteomes. Quantities of the significantly changed proteins are shown in their corresponding COG categories, and the number after each letter indicates total protein numbers within each COG (16). The functional categories are abbreviated as follows: C, energy production and conversion; E, amino acid metabolism and transport; F, nucleotide metabolism and transport; G, carbohydrate metabolism and transport; H, coenzyme metabolism; I, lipid metabolism; J, translation, including ribosome structure and biogenesis; K, transcription; L, replication, recombination, and repair; M, cell wall structure and biogenesis and outer membrane; O, molecular chaperones and related functions; P, inorganic ion transport and metabolism; Q, secondary metabolite biosynthesis, transport, and catabolism; R, general function predicted only; S, no functional prediction; T, signal transduction; U, intracellular trafficking, secretion, and vesicular transport; V, defense mechanisms.