Table 1.

Comparison of pivoxil esters to their acid forms in growth inhibition of the U937 histiocytic lymphoma cell line.^a

Pivoxil : H #	Pivoxil IC50 : H IC50 (μM)	Ratio IC50 Pivoxil : IC50 H
1 : 8	5.3 ± 0.4 : 980 ± 80	1 : 185
2 : 9	0.68 ± 0.05 : 1,100 ± 200	1: 1,618
3 : 10	5.6 ± 0.7 : 29 ± 1	1 : 5
4 : 11	3.6 ± 0.3 : 200 ± 3	1 : 56
5 : 12	5.3 ± 0.4 : 68 ± 1	1 : 13
6 : 13	2.4 ± 0.0 : 150 ± 6	1 : 63
7 : 14	0.26 ± 0.01 : 26 ± 1	1 : 100

^aExperimental details are described in Supporting Information, Figure S2.