Table 1.
Results of the maximum-likelihood modeling of normal tissue complication probabilities as a function of functional lung volume metrics (fVXGy) and total lung volume metrics (VXGy). Values in parentheses represent the 95% confidence interval of the fitting parameters.
| Grade 2+ Pneumonitis | Grade 3+ Pneumonitis | |||||||
|---|---|---|---|---|---|---|---|---|
| Dose Metric | p-Value | AUC | m | TD50 | p-Value | AUC | m | TD50 |
| fV5Gy | <0.01 | 0.693 | 0.479 (0.185-0.773) | 72.7 (5.1-140.3) | 0.82 | 0.537 | 1.020 (-0.304-2.343) | 427.1 (-3323.0-4177.2) |
| V5Gy | 0.05 | 0.637 | 0.577 (0.100-1.054) | 77.9 (-22.5-178.2) | 0.68 | 0.506 | 1.889 (-3.427-7.205) | -105.3 (-679.1-468.5) |
| fV10Gy | <0.01 | 0.718 | 0.530 (0.210-0.850) | 54.1 (4.1-104.0) | 0.27 | 0.574 | 0.689 (0.143-1.235) | 106.4 (-101.0-313.8) |
| V10Gy | 0.13 | 0.614 | 0.757 (-0.003-1.517) | 63.8 (-40.9-168.6) | 0.85 | 0.537 | 1.409 (-1.388-4.207) | -254.3 (-2939.6-2431.1) |
| fV20Gy | <0.01 | 0.707 | 0.548 (0.254-0.841) | 35.9 (6.7-65.1) | 0.01 | 0.674 | 0.473 (0.232-0.714) | 50.8 (3.8-97.7) |
| V20Gy | 0.36 | 0.545 | 1.095 (-0.464-2.653) | 52.7 (-83.3-188.7) | 0.49 | 0.519 | 0.742 (-0.072-1.557) | 90.5 (-184.2-365.2) |
| fV30Gy | <0.01 | 0.682 | 0.670 (0.286-1.054) | 30.3 (3.4-57.2) | 0.01 | 0.671 | 0.517 (0.260-0.775) | 43.6 (2.9-84.3) |
| V30Gy | 0.75 | 0.508 | 1.934 (-2.613-6.480) | 76.0 (-430.0-582.1) | 0.53 | 0.519 | 0.787 (-0.080-1.654) | 83.1 (-194.2-360.4) |
| fMLD | <0.01 | 0.723 | 0.672 (0.440-0.904) | 30.3 (13.3-47.4) | 0.02 | 0.648 | 0.519 (0.268-0.770) | 43.7 (13.3-74.2) |
| MLD | 0.12 | 0.584 | 0.672 (0.003-1.41) | 26.3 (-15.6-68.1) | 0.29 | 0.545 | 0.586 (0.017-1.155) | 40.8 (-44.6-126.1) |