Table 4.

Normal tissue complication probabilities for grade 3+ radiation pneumonitis are presented for the average functional lung volume metrics for the clinical plans and functional avoidance plans. In parentheses is the 95% confidence intervals in the NTCP values and toxicity reduction as determined during bootstrap analysis. The range of toxicity reductions among the 30 patients re-planned with functional avoidance techniques is also presented. Positive numbers correspond to a decreased risk in toxicity while negative numbers correspond to an increased risk of toxicity.

Grade 3+ Toxicity
Dose Metric for NTCP Model	Toxicity Probability of the Mean – Clinical Plan	Toxicity Probability of the Mean – Functional Plan	Absolute Reduction	Range of Reductions
fV20Gy	19.5% (9.3%-29.5%)	15.9% (6.3%-25.2%)	3.6% (0.8% - 6.1%)	-15.4% - 14.3%
fV30Gy	19.6% (9.1%-29.4%)	14.7% (5.4%-24.0%)	4.8% (0.8% - 8.4%)	-7.0% - 14.7%
fMLD	20.3% (10.0%-30.4%)	17.9% (7.9%-27.3%)	2.4% (0.2% - 4.3%)	-24.4% - 16.4%