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. 2017 Sep 19;8(5):e01205-17. doi: 10.1128/mBio.01205-17

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Copyright © 2017 Andrade et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 4 — Trajectories of neutralizing antibody responses 3, 6, 12, and 18 months post-primary DENV3 infection. The neutralizing antibody titers to rDENV4/3-M14, DENV3, DENV4, and the overall cross-reactive titers (geometric mean of DENV1, DENV2, and DENV4 NT₅₀ values) from 12 individuals were analyzed. (A) rDENV4/3-M14 titers follow similar trajectory to DENV3 titers in an individual with a constant proportion of the 5J7 response. (B) Increase of rDENV4/3-M14 titers between 3 and 6 months, with parallel decay of cross-reactive titers, indicates affinity maturation in an individual who displayed an increased proportion of the 5J7 response. (C) Increase in rDENV4/3-M14 titers between 12 and 18 months indicates possible homotypic reexposure in an individual with an increased proportion of the 5J7 response. (D) Increase in cross-reactive titers between 12 and 18 months indicates possible heterotypic reexposure in an individual who displayed a decreased proportion of the 5J7 response over time.