FIG 6 .

Neutralizing titers and proportion of the DENV3 response attributable to the 5J7 amino acid residues contained in the rDENV4/3-M14 and rDEV4/3-M16 viruses 3 and 18 months post-primary DENV3 infection. (A) Neutralizing antibody titers to rDENV4/3-M14 and to the chimeric virus with a larger footprint of the 5J7 epitope (rDENV4/3-M16) in primary DENV3 plasma 3 and 18 months postinfection (n = 30). (B) Proportion of the DENV3 neutralizing response attributable to the 5J7 amino acid residues transplanted into the DENV4 backbone in the rDENV4/3-M14 and rDENV4/3-M16 viruses 3 and 18 months post-primary DENV3 infection (n = 30). (C) Representation of the number of individuals who strongly recognize the rDENV4/3-M14 and rDENV4/3-M16 viruses or individuals who are refractory to rDENV4/3-M14 virus and only recognize the rDENV4/3-M16 virus at 3 and 18 months postinfection. The criteria for “low rDENV4/3-M14” or “low rDENV4/3-M16” was 0 to 10% of the DENV3 neutralizing response due to the 5J7 epitope, whereas “moderate/high rDENV4/3-M14” or “moderate/high rDENV4/3-M16” was defined as a proportion higher than 10%. The NT₅₀ and the proportion of the 5J7 response were compared by two-way ANOVA (n = 30), where * represents P < 0.05 and ** represents P < 0.01.