Table II.
Association between Drosha and Dicer mRNA expression levels and clinicopathological parameters.
| Drosha | Dicer | |||||
|---|---|---|---|---|---|---|
| Characteristic | Low | High | P-value | Low | High | P-value |
| Sex | 0.070c | 0.092b | ||||
| Male | 43 | 9 | 42 | 10 | ||
| Female | 16 | 9 | 24 | 1 | ||
| Age, years | 0.190b | 0.056b | ||||
| ≤50 | 7 | 0 | 4 | 3 | ||
| >50 | 52 | 18 | 62 | 8 | ||
| T stage | 0.308a | 0.366a | ||||
| T1 | 3 | 2 | 4 | 1 | ||
| T2 | 11 | 2 | 10 | 3 | ||
| T3 | 36 | 14 | 44 | 6 | ||
| T4 | 9 | 0 | 8 | 1 | ||
| N stage | 0.542a | 0.957a | ||||
| N0 | 35 | 11 | 39 | 7 | ||
| N1 | 13 | 4 | 15 | 1 | ||
| N2 | 9 | 6 | 10 | 3 | ||
| N3 | 2 | 0 | 2 | 0 | ||
| M stage | 0.585b | 0.146b | ||||
| Negative | 54 | 18 | 63 | 9 | ||
| Positive | 5 | 0 | 3 | 2 | ||
| BMI | 0.614a | 0.872a | ||||
| ≤18.5 | 1 | 1 | 1 | 1 | ||
| 18.5–24.9 | 37 | 12 | 44 | 5 | ||
| 25-29.9 | 20 | 4 | 19 | 5 | ||
| >30 | 1 | 1 | 2 | 0 | ||
| CEA (ng/ml) | 0.268c | 1.000b | ||||
| >5 | 15 | 7 | 19 | 3 | ||
| ≤5 | 44 | 11 | 47 | 8 | ||
| Dicer | 1.000b | |||||
| Low | 50 | 16 | ||||
| High | 9 | 2 | ||||
| Drosha | 1.000b | |||||
| Low | 50 | 9 | ||||
| High | 16 | 2 | ||||
a
Linear-by-linear association;
b
Fisher's exact test;
c
Pearson's χ2 test. T, tumor; N, node; M, metastasis; CEA, carcinoembryonic antigen.