Fig. 10.

Schematic of the impact of S1R knockout on rd10 mouse retinal degeneration. The time course shows autonomous rod degeneration featuring apoptosis initiated by a mutation in the rod photoreceptor Pde6b gene, followed by secondary cone death with necroptosis as the major mechanism. S1R knockout in the rd10 mouse retina enhances ER stress and autophagy at early stage but leads to autophagy inhibition and Müller glial activation at later time points, which are accompanied by exaggerated rod and cone death