Table 4.

Summary of interactions computed by VERMONT for mutations (nsSNPs) in the p53 (PDBid 1TSR) core domain that were experimentally characterized

	Aromatic stacking		Charged attractive		Charged repulsive		Disulfide bridge		Hydrogen bond		Hydrophobic
	μ	σ	μ	σ	μ	σ	μ	σ	μ	σ	μ	σ
Arg273His	1.00	0.00	6.79	1.51	1.72	1.00	0.00	0.00	4.49	0.85	1.00	0.00
Gly245Ser	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.90	0.61	1.00	0.00
Arg249Ser	0.00	0.00	3.56	0.68	1.20	0.76	0.00	0.00	5.09	1.46	1.44	0.50
Arg248Ala	0.00	0.00	1.00	0.00	2.13	0.88	0.00	0.00	3.04	0.50	0.00	0.00
Cys242Ser	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.98	0.59	1.00	0.00
His168Arg	0.00	0.00	1.23	0.82	1.21	0.84	0.00	0.00	3.97	1.01	1.07	0.30
Val143Ala	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	3.92	0.31	1.16	0.40
Ile195Thr	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.00	2.00	0.00	2.07	0.89