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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Feb 2;2(4):346–354. doi: 10.1016/j.bpsc.2017.01.009

Figure 1. Self-reported antisocial behavior (AB) predicts less ventral striatum and vlPFC reactivity during the anticipation of rewards.

Figure 1

(A) Self-reported AB is negatively correlated with ventral striatum reactivity in the right ventral striatum region of interest (centered at the peak voxel, MNI: 10, 14, -6, t=−2.73, k=164). This finding emerges across multiple measures of AB and when controlling for CU traits and other psychiatric diagnoses. (B) Scatterplot of Self-Reported AB and ventral striatum reactivity during anticipation of rewards. (C) Self-reported AB is negatively correlated with activity in the left middle frontal gyrus (ventrolateral prefrontal cortex) and activity in a cluster extending from the right VS into the broader caudate during anticipation of rewards (centered at the second peak voxel, MNI: 10 14 −6; t = 3.06, k=625). The VS/caudate cluster remains (and demonstrated suppression effects) when controlling for CU traits and other psychiatric diagnoses. The left middle frontal gyrus cluster was only significant when partialling out variance of CU traits and other psychiatric diagnoses (centered at the peak voxel, MNI: −32, 60, −2; t = −3.36, k =601). (D) Scatterplot of Self-Reported AB and middle frontal gyrus (ventrolateral prefrontal cortex) reactivity during anticipation of rewards